Bixib-TC

Description

Bixib-TC 4mg

Etoricoxib 60 mg and Thiocolchicoside 4 mg

This is a fixed-dose combination used for the treatment of painful musculoskeletal conditions, especially when inflammation and muscle spasm coexist. It combines:

Etoricoxib: A selective COX-2 inhibitor NSAID with potent anti-inflammatory and analgesic effects.
Thiocolchicoside: A muscle relaxant with anti-inflammatory and analgesic properties, derived from the plant Colchicum autumnale.

Mechanism of Action

Etoricoxib:

Selectively inhibits cyclooxygenase-2 (COX-2)
Reduces prostaglandin synthesis, which causes pain and inflammation.
Spares COX-1 (thus has fewer GI side effects than traditional NSAIDs).

Thiocolchicoside:

Acts as a GABA-A receptor agonist and also modulates glycine receptors.
Leads to muscle relaxation by inhibiting spinal reflexes and muscle contractions.
Does not cause sedation like other muscle relaxants (e.g., benzodiazepines).

Indications (Uses)

This combination is typically prescribed for:

Acute low back pain
Cervical or lumbar spondylosis
Muscle spasms
Sprains or strains
Post-traumatic muscle stiffness
Sciatica or disc herniation with inflammation and spasm
Arthritis with muscular pain

Dosage & Administration

Usual adult dose:
One tablet once or twice daily (based on severity and clinical judgment)
Route: Oral, preferably after food to reduce gastric irritation.