DOCTONIX 5 ML INJ

It is primarily used in a hospital setting and administered via intravenous infusion under medical supervision.

Mode of Action

Dobutamine is a selective adrenergic agonist that primarily stimulates beta-1 receptors in the heart, leading to increased heart rate (chronotropy) and force of contraction (inotropy). The main effects include

  • Positive Inotropic Effect: Increases heart muscle contraction, enhancing cardiac output.
  • Positive Chronotropic Effect: Increases heart rate.
  • Mild Vasodilation: Helps reduce afterload (resistance the heart pumps against).
  • Minimal Alpha-1 Effect: Reduces vasoconstriction.

Indications

  • Congestive Heart Failure (CHF)
  • Cardiogenic Shock
  • Post-cardiac Surgery Support
  • Severe Hypotension
  • Stress Echocardiography

Doses

  • Initial Dose (Adults): 2-5 mcg/kg/min via IV infusion.
  • Titration: Up to 20 mcg/kg/min based on response.
  • Dilution: Mix 250 mg concentrate with 50-100 mL of IV solution
  • (e.g., saline, dextrose).
Category:

Description

Dobutamine Concentrate IP (Indian Pharmacopoeia) is a medication used in the management of heart failure, shock, and other cardiovascular conditions requiring improved cardiac output. It is a synthetic catecholamine that primarily acts on beta-1 adrenergic receptors in the heart and, to a lesser extent, beta-2 receptors in the lungs and blood vessels. The concentrate is typically diluted before intravenous administration.

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