Tiziful

Tigecycline 50mg for Injection

Tiziful (Tigecycline) is a broad-spectrum antibiotic used to treat a variety of infections caused by susceptible bacteria. It belongs to the class of drugs known as glycylcyclines and works by inhibiting bacterial protein synthesis.

Here are some key points about tigecycline:

1. Mechanism of action: Tigecycline works by binding to the 30S ribosomal subunit of bacteria, thereby inhibiting protein synthesis. It is effective against both Gram-positive and Gram-negative bacteria, including drug-resistant strains.
2. Indications: Tigecycline is commonly used to treat complicated skin and skin structure infections, intra-abdominal infections, and community-acquired pneumonia. It is also sometimes used for other types of infections when alternative treatment options are limited.
3. Administration: Tigecycline is administered intravenously (IV) and is usually given as a loading dose followed by maintenance doses every 12 hours. The dosage and duration of treatment depend on the type and severity of the infection.
4. Antibiotic resistance: While tigecycline is effective against many bacteria, some strains have developed resistance to this drug. It is important to use tigecycline judiciously to minimize the development of resistance.
5. Side effects: Common side effects of tigecycline include nausea, vomiting, diarrhea, abdominal pain, and headache. It may also cause changes in liver function tests and an increased risk of fungal infections. Tigecycline should be used with caution in patients with pre-existing liver disease.
6. Precautions and contraindications: Tigecycline is generally not recommended for use in children under the age of eight due to the risk of tooth discoloration and impaired bone development. It should also be avoided in pregnant women, as its safety during pregnancy has not been established.
7. Drug interactions: Tigecycline may interact with certain medications, such as warfarin, leading to an increased risk of bleeding. It is important to inform your healthcare provider about all the medications you are taking before starting tigecycline.