Description
BARENIA-D 75 mg
Pregabalin 75mg + Duloxetine 20mg
- Pregabalin 75 mg and Duloxetine 20 mg are medications that are used to treat various medical conditions, often in combination for certain types of pain and mood disorders. Here is a detailed explanation of each medication and how they may be used together:
- Mechanism of Action
- Pregabalin works by affecting the neurotransmitters in the brain, particularly by binding to calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters like glutamate, norepinephrine, and substance P, thereby decreasing nerve excitability and helping to alleviate pain, anxiety, and seizures.
- Duloxetine works by inhibiting the reuptake of serotonin and norepinephrine in the brain, leading to increased levels of these neurotransmitters, which can improve mood, reduce pain, and alleviate anxiety. It also has effects on pain pathways, making it useful for conditions involving both mood and pain.
Indication:
- Neuropathic Pain
- Fibromyalgia
- Generalized Anxiety Disorder (GAD
- Seizures
- Neuropathic Pain
- Fibromyalgia
- Generalized Anxiety Disorder (GAD)
- Seizures
- Dosage:
: One capsule/tablet once or twice daily
- Once daily at bedtime — preferred if sedation is a concern.
- Twice daily (every 12 hours) — for more consistent pain or symptom control, especially in neuropathic pain.






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